Cellular context shapes cyclic nucleotide signaling in neurons through multiple levels of integration

Intracellular signaling with cyclic nucleotides are ubiquitous pathways, yet the dynamics of these signals profoundly differ in different cell types. Biosensor imaging experiments, by providing direct measurements intact cellular environment, reveal which receptors activated neuromodulators and how coincidence is integrated at various levels cascade. Phosphodiesterases appear as one important determinant cross-talk between pathways. Finally, analysis signal that striatal medium-sized spiny neuron obey a logic than other brain regions such cortex, probably relation function this region efficiently detects transient dopamine.